Antibodies

Conventional methods for antibody discovery and optimization struggle to meet the demands of modern medicine. These workflows rely on labor-intensive processes and incremental improvements, often constrained by biases in natural and synthetic systems. As a result, critical therapeutic opportunities – such as targeting conserved or cryptic epitopes or designing bispecific antibodies – are frequently missed. Traditional approaches often prioritize affinity at the expense of stability, specificity, or manufacturability, necessitating further rounds of optimization. What’s needed is a smarter, more efficient way to unlock the full potential of antibody therapeutics while addressing these challenges head-on.

By harnessing insights from billions of natural antibodies, our AI platform brings unique capabilities to antibody discovery and optimization. At its core is the ability to rapidly explore the sequence space of human-like antibodies. This capability unlocks access to unprecedented sequence diversity, allowing us to uncover solutions that traditional methods might overlook, such as the complete redesign of key binding regions.

In addition to enabling unparalleled exploration of sequence diversity, our AI platform excels at fine-grained optimization of critical antibody properties, including binding affinity, stability, and manufacturability. Using our models, we can precisely tune individual residues to achieve an ideal balance of these attributes. This capability allows us to optimize antibodies not only for target engagement but also for robustness in real-world therapeutic settings, such as long-term storage, complex biological environments, and scalable production processes.

With our AI platform that seamlessly combines vast sequence exploration and precise property optimization, we are advancing the development of next-generation antibody therapeutics. Our approach overcomes the limitations of traditional methods, enabling the discovery and refinement of antibodies that meet the complex demands of modern medicine. Whether tackling cryptic targets, engineering multi-specifics, or ensuring manufacturability, our platform delivers innovative solutions designed for real-world impact.